Aging is Now Optional w/ David Sinclair | EP #60

Added: Aug 27, 2023

Dr. Sinclair explains that aging is not simply the result of wear and tear on the body, but rather a loss of information in our cells. He introduces the concept of the epigenome, which controls the regulation of genes, and explains that most diseases and disabilities are controlled by the epigenome rather than our genes. He discusses his discovery of a backup copy of information in every cell, which can be accessed and used to reset the biological age of cells. This breakthrough has allowed him to reverse aging in mice and even rejuvenate the brains of mice with dementia. Dr. Sinclair believes that there is no upper limit to human aging and that we can extend our lifespan beyond 120 years. He points to the fact that we have been able to extend the lifespan of every species we have studied and that there are many species that live longer than humans. He also discusses the concept of longevity escape velocity, which is the idea that for every year we are alive, science can extend our life for more than a year. He believes that we are already at the point where we can achieve this, but it is not widely available yet. Dr. Sinclair talks about the importance of AI and technology in advancing the field of aging research. He explains that AI can help us analyze and synthesize vast amounts of data, leading to exponential increases in our understanding of aging and the development of new therapies. He also discusses the potential of gene therapies and the use of adeno-associated viruses to target specific tissues and organs. He explains that these therapies have the potential to work for the entire body, not just specific tissues. Dr. Sinclair discusses the importance of NAD, a molecule required for life, and its role in aging and mitochondrial function. He explains that boosting NAD levels can rejuvenate mitochondria and improve health and longevity. He also talks about his own lifestyle practices, including taking rapamycin and metformin, following a vegan diet, practicing intermittent fasting, and exercising regularly. He emphasizes the importance of maintaining healthy mitochondria and protein intake to prevent muscle loss. Dr. Sinclair concludes by discussing his future research plans and the importance of developing age reversal technologies that are accessible and affordable for everyone. He believes that the field of aging research is rapidly advancing and that we are on the cusp of major breakthroughs in age reversal and longevity. Overall, Dr. Sinclair's research and insights offer hope for a future where aging is optional and humans can live longer, healthier lives. His work has the potential to revolutionize the field of medicine and transform our understanding of aging and longevity.